柚皮素烟酰胺共晶的制备及表征

许丹, 李彤, 张婷婷, 金波, 马辰

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (4) : 291-296.

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PDF(1799 KB)
中国药学杂志 ›› 2019, Vol. 54 ›› Issue (4) : 291-296. DOI: 10.11669/cpj.2019.04.007
论著

柚皮素烟酰胺共晶的制备及表征

  • 许丹, 李彤, 张婷婷, 金波, 马辰*
作者信息 +

Preparation and Characterization of Naringenin Nicotinamide Co-crystal

  • XU Dan, LI Tong, ZHANG Ting-ting, JIN Bo, MA Chen*
Author information +
文章历史 +

摘要

目的 制备一种新型柚皮素共晶,以改善柚皮素水溶性差等问题。方法 采用溶剂挥发法,以乙酸乙酯为溶剂制备柚皮素烟酰胺共晶,利用红外光谱法(IR),差示扫描量热法(DSC),X射线粉末衍射法(XRPD)以及扫描电镜(SEM)等技术对其进行表征。结果 通过测定不同pH溶液的平衡溶解度,发现柚皮素烟酰胺共晶相比于柚皮素,其平衡溶解度有了显著提高。结论 该方法能够提高柚皮素的溶解度,简单易行,为进一步改善柚皮素溶解度打下基础。

Abstract

OBJECTIVE To prepare a novel naringenin co-crystal to improve the poor water solubility of the compound. METHODS Solvent volatilization method was used to prepare naringenin nicotinamide co-crystal, with ethyl acetate as solvent. It is characterized by the technology of infrared spectroscopy (IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), scanning electron microscopy (SEM) and other techniques. RESULTS By measuring the equilibrium solubility of different pH solutions, it was found that the naringenin nicotinamide co-crystal has a significantly improved equilibrium solubility compared with naringenin. CONCLUSION This method can improve the solubility of naringenin, which is simple and easy, and lays the foundation for further study of naringenin co-crystal.

关键词

共晶 / 柚皮素 / 烟酰胺 / 平衡溶解度

Key words

co-crystal / naringenin / nicotinamide / equilibrium solubility

引用本文

导出引用
许丹, 李彤, 张婷婷, 金波, 马辰. 柚皮素烟酰胺共晶的制备及表征[J]. 中国药学杂志, 2019, 54(4): 291-296 https://doi.org/10.11669/cpj.2019.04.007
XU Dan, LI Tong, ZHANG Ting-ting, JIN Bo, MA Chen. Preparation and Characterization of Naringenin Nicotinamide Co-crystal[J]. Chinese Pharmaceutical Journal, 2019, 54(4): 291-296 https://doi.org/10.11669/cpj.2019.04.007
中图分类号: R284   

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基金

“重大新药创制”国家科技重大专项资助(2012ZX09301002-001-006)
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